Go to the JANA home page to access the full journal or individual articles. Included in this edition:

Editorial: Genetic Testing: Between Hope and Hype by Bernd Wollschlaeger, MD, FAAFP

REVIEW ARTICLE:Retarding Cognitive Decline with Science-based Nutraceuticals by Joshua Reynolds. Richard D. Hamill, PhD, Rita Ellithorpe, MD, Robert Settineri, MS

ORIGINAL RESEARCH: A Comparison of Injected and Orally Administered by Vaclav Vetvicka, PhD, Jana Vetvickova, MS - University of Louisville, Department of Pathology, Louisville, KY

ORIGINAL RESEARCH: A Standardized Withania Somnifera Extract Significantly Reduces Stress-related Parameters in Chronically Stressed Humans: A Double-blind, Randomized, Placebo-controlled Study by Biswajit Auddy, PhD; Jayaram Hazra, PhD; Achintya Mitra, MD; Bruce Abedon, PhD; Shibnath Ghosal, PhD

PILOT STUDY: Oral Tolerability of Cystine-Rich Whey Protein Isolate in Autism by Janet K. Kern, PhD; Bruce D. Grannemann, MA; Jimmy Gutman, MD, FACEP

META-ANALYSIS STUDY: The Effect of Vitamin C Supplementation on Blood Pressure with Hypertensive Patients: A Meta-analysis of Randomized Controlled Trials. by Marc P. McRae MSc, DC, FACN

Also in this edition: reports from the Fall 2007 ANA Continuing Medical Education Conference in Memphis, TN.

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Speakers for the ANA Spring Continuing Medical Education Conference April 19th, 2008 - Wyndham Hotel - Phoenix, AZ

For a complete conference brochure, please visit the ANA website in December, and click on ANA Conferences, or phone the ANA Customer Service Dept. at 800-566-3622.

Speakers and Topics for the Conference:

Tieraona Low Dog, MD Director of Education for the Program in Integrative Medicine Clinical Assistant Professor, Department of Medicine University of Arizona College of Medicine

Topic: Living in the Balance: Strategies for Optimal Health

In her talk Dr. Low Dog will review the evidence of safety and benefit for dietary supplements commonly recommended for health, the scientific evidence for mind-body approaches to pain, anxiety, and depression, and review the scientific evidence for nutritional approaches for the prevention of cardiovascular disease and common cancers.

In addition to her work as a clinician and educator, Dr. Low Dog has been involved in national health policy and regulatory issues for more than a decade. In 2000, she was appointed by President Clinton to serve on the White House Commission of Complementary and Alternative Medicine. She just recently completed her 3 year term in February 2007 as a member of the Advisory Council for the National Institutes of Health National Center for Complementary and Alternative Medicine (NCCAM). Dr. Low Dog has served as the elected Chair of the United States Pharmacopeia Dietary Supplements and Botanicals Expert Committee since 2000. Her many honors of distinction include the Martina de la Cruz medal for her work with indigenous medicines (1998), Time magazine’s “Innovator in Complementary and Alternative Medicine” (2001), the Burt Kallman Scientific Award (2007) and NPR’s People’s Pharmacy award (2007).

Dr. Low Dog serves on the editorial/advisory boards of Menopause and Explore journals, Prevention Magazine, and the American Botanical Council. She has appeared on ABC’s 20/20, CNN, and is a frequent guest NPR’s The People’s Pharmacy.

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John T. Landrum, PhD Professor of Chemistry and Associate Dean University Graduate School Florida International University Miami, FL

Topic: The Role of Nutrition and Dietary Supplements in Preventing and Treating Age-Related Macular Degeneration (AMD): Guidelines for the Clinical Practice

For the past 15 years, Richard Bone, professor of physics, and John Landrum, professor of chemistry, at Florida International University have collaborated on research on the macular pigment and its possible connection with age-related macular degeneration (AMD).

In a paper published in 1985, Bone and Landrum revealed that the human macular pigment is composed of lutein and zeaxanthin, two pigments that are found in many vegetables and fruits. "We now know it's composed exclusively of these two carotenoids," Landrum said. "The high concentration of these two carotenoids is one of the surprising features of the macular pigment. This is evidence that the macular pigment is functionally significant."

More than a decade of research led up to the studies Bone and Landrum have been conducting the past two years. Based on evidence suggesting the protective role of the macular pigment - and research noting an association between a particular type of macular degeneration and a diet low in lutein and zeaxanthin - they wanted to address two related issues: Do lower than normal levels of macular pigmentation represent a risk factor for the development of AMD? Can dietary supplements of lutein and/or zeaxanthin increase pigment levels in the macula, thereby providing additional protection against AMD or slowing its development

At the ANA Spring CME Conference, Dr. Landrum will share details on his research, and the role of the carotenoids Lutein and Zeaxanthin in the prevention of AMD.

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Manfred Lamprecht, Ph.D. Institute of Physiological Chemistry Medical University of Graz Graz, Austria

Topic: Oxidative stress, antioxidants and exercise: Guidelines for the clinical practice

Dr. Lamprecht has spent over a decade focusing on research that deals with the influence of nutrition, vitamin supplementation and exercise on free radical metabolism. In addition to his teaching and research at the Medical University of Graz, he also works with the Institute of Training Sciences and Sport Consulting in Graz, Austria. Dr. Lamprecht will also present data from a recently completed study on a phytonutrient supplement.

Dr. Lamprecht is a native of Graz, Austria. To Americans, Graz is also known as the hometown of California Governor Arnold Schwarzenegger. Dr. Lamprecht earned his degrees in sports science from Karl Franzens University in Graz. Dr. Lamprecht has been teaching University classes in the areas of sports nutrition and free radical science at both the Medical University of Graz and Karl Franzens University, for over ten years. He also teaches public health sciences with the Styria Health Association. Dr. Lamprecht is interested in the importance of good nutrition, including fruits and vegetables, for athletes and other fit people.

For more information, contact: Jennifer Kohm jkohm@cw.bc.ca 604-875-2401 Child & Family Research Institute

---------------------------------------------- Bernd Wollschlaeger, MD Clinical Professor Dept. of Family Medicine, University of Miami School of Medicine, Medical Director, Aventura Famiy Health Center, North Miami Beach, Fl

Topic: Nutrients and Genes: Nutrigenomics and Personalized Health Care OBJECTIVES: 1)Understand a basic model describing relationship between gene expression and disease development 2)Review environmental and nutritional interactions and gene expression 3)Identify potential nutritional modification to maximize optimal health maintenance

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The Food and Drug Administration (FDA) released a final rule on current Good Manufacturing Practices (cGMPs) for dietary supplements, establishing requirements to ensure products are made in a consistent, quality manner and are accurately labeled and free from impurities. This much anticipated ruling applies to companies that manufacture, package or store dietary supplements; FDA management explained, for the most part, retailers are not included in this rule, while health care practitioners will be considered on a case-by-case basis. The final rule is effective August 24, 2007, but there is a 36-month phase-in period for companies to comply, depending on size. “The final rule will help ensure that dietary supplements are manufactured with controls that result in a consistent product free of contamination, with accurate labeling,” said Robert E. Brackett, Ph.D., director of FDA’s Center for Food Safety and Applied Nutrition. Among the rule’s 800-plus pages of requirements, manufacturers will be compelled to evaluate the identity, purity, strength and composition of their dietary supplements. This helps to ensure finished products contain actual labeled contents, but not adulterants such as pesticides, bacteria or heavy metals. If dietary supplements contain contaminants or do not contain the dietary ingredient they are represented to contain, FDA would consider those products adulterated or misbranded. The rule further contains requirements for establishing quality control procedures, designing and constructing manufacturing plants, and testing ingredients and the finished product, as well as provisions for handling consumer product complaints and for recordkeeping—including standard operating procedures (SOPs).

For the FDA's Fact Sheet on both the Final GMP rule and the interim rule on testing, visit http://www.cfsan.fda.gov/~dms/dscgmps6.html or you can click on the link found at the bottom of this home page.

For a copy of the complete report: Current Good Manufacturing Practice in Manufacturing, Packaging, Labeling, or Holding Operations for Dietary Supplements; Final Rule Go to http://www.cfsan.fda.gov/~lrd/fr07625a.html or click on the link found at the bottom of the home page.

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